Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis
Identifieur interne : 000103 ( Main/Exploration ); précédent : 000102; suivant : 000104Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis
Auteurs : Samira Chabab [Belgique] ; Fabienne Lescroart [Belgique] ; Steffen Rulands [Royaume-Uni] ; Navrita Mathiah [Belgique] ; Benjamin D. Simons [Royaume-Uni] ; Cédric Blanpain [Belgique]Source :
- Cell Reports [ 2211-1247 ] ; 2015.
Abstract
The heart arises from distinct sources of cardiac progenitors that independently express
Url:
DOI: 10.1016/j.celrep.2015.12.013
PubMed: 26725109
PubMed Central: 4709258
Affiliations:
- Belgique, Royaume-Uni
- Angleterre, Angleterre de l'Est, Région de Bruxelles-Capitale
- Bruxelles, Cambridge
- Université de Cambridge, Université libre de Bruxelles
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wicri:level="4"><nlm:aff id="aff1">Université Libre de Bruxelles, IRIBHM, Brussels 1070, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Libre de Bruxelles, IRIBHM, Brussels 1070</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Lescroart, Fabienne" sort="Lescroart, Fabienne" uniqKey="Lescroart F" first="Fabienne" last="Lescroart">Fabienne Lescroart</name><affiliation wicri:level="4"><nlm:aff id="aff1">Université Libre de Bruxelles, IRIBHM, Brussels 1070, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Libre de Bruxelles, IRIBHM, Brussels 1070</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Rulands, Steffen" sort="Rulands, Steffen" uniqKey="Rulands S" first="Steffen" last="Rulands">Steffen Rulands</name><affiliation wicri:level="4"><nlm:aff id="aff2">Cavendish Laboratory, Department of Physics, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cavendish Laboratory, Department of Physics, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Mathiah, Navrita" sort="Mathiah, Navrita" uniqKey="Mathiah N" first="Navrita" last="Mathiah">Navrita Mathiah</name><affiliation wicri:level="4"><nlm:aff id="aff1">Université Libre de Bruxelles, IRIBHM, Brussels 1070, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Libre de Bruxelles, IRIBHM, Brussels 1070</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Simons, Benjamin D" sort="Simons, Benjamin D" uniqKey="Simons B" first="Benjamin D." last="Simons">Benjamin D. Simons</name><affiliation wicri:level="4"><nlm:aff id="aff2">Cavendish Laboratory, Department of Physics, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cavendish Laboratory, Department of Physics, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Blanpain, Cedric" sort="Blanpain, Cedric" uniqKey="Blanpain C" first="Cédric" last="Blanpain">Cédric Blanpain</name><affiliation wicri:level="4"><nlm:aff id="aff1">Université Libre de Bruxelles, IRIBHM, Brussels 1070, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Libre de Bruxelles, IRIBHM, Brussels 1070</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">WELBIO, Université Libre de Bruxelles, Brussels 1070, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>WELBIO, Université Libre de Bruxelles, Brussels 1070</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></analytic><series><title level="j">Cell Reports</title><idno type="eISSN">2211-1247</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>The heart arises from distinct sources of cardiac progenitors that independently express <italic>Mesp1</italic> during gastrulation. The precise number of <italic>Mesp1</italic> progenitors that are specified during the early stage of gastrulation, and their clonal behavior during heart morphogenesis, is currently unknown. Here, we used clonal and mosaic tracing of <italic>Mesp1</italic>-expressing cells combined with quantitative biophysical analysis of the clonal data to define the number of cardiac progenitors and their mode of growth during heart development. Our data indicate that the myocardial layer of the heart derive from ∼250 <italic>Mesp1</italic>-expressing cardiac progenitors born during gastrulation. Despite arising at different time points and contributing to different heart regions, the temporally distinct cardiac progenitors present very similar clonal dynamics. These results provide insights into the number of cardiac progenitors and their mode of growth and open up avenues to decipher the clonal dynamics of progenitors in other organs and tissues.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Auman, H J" uniqKey="Auman H">H.J. Auman</name></author><author><name sortKey="Coleman, H" uniqKey="Coleman H">H. Coleman</name></author><author><name sortKey="Riley, H E" uniqKey="Riley H">H.E. Riley</name></author><author><name sortKey="Olale, F" uniqKey="Olale F">F. Olale</name></author><author><name sortKey="Tsai, H J" uniqKey="Tsai H">H.J. Tsai</name></author><author><name sortKey="Yelon, D" uniqKey="Yelon D">D. Yelon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailey, N T J" uniqKey="Bailey N">N.T.J. Bailey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buckingham, M" uniqKey="Buckingham M">M. 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Yokoyama</name></author><author><name sortKey="Onoe, H" uniqKey="Onoe H">H. Onoe</name></author><author><name sortKey="Eguchi, M" uniqKey="Eguchi M">M. Eguchi</name></author><author><name sortKey="Yamaguchi, S" uniqKey="Yamaguchi S">S. Yamaguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tam, P P" uniqKey="Tam P">P.P. Tam</name></author><author><name sortKey="Beddington, R S" uniqKey="Beddington R">R.S. Beddington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Underwood, E E" uniqKey="Underwood E">E.E. Underwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wessels, A" uniqKey="Wessels A">A. Wessels</name></author><author><name sortKey="Sedmera, D" uniqKey="Sedmera D">D. Sedmera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wicksell, S D" uniqKey="Wicksell S">S.D. Wicksell</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li><li>Université libre de Bruxelles</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Chabab, Samira" sort="Chabab, Samira" uniqKey="Chabab S" first="Samira" last="Chabab">Samira Chabab</name></region><name sortKey="Blanpain, Cedric" sort="Blanpain, Cedric" uniqKey="Blanpain C" first="Cédric" last="Blanpain">Cédric Blanpain</name><name sortKey="Blanpain, Cedric" sort="Blanpain, Cedric" uniqKey="Blanpain C" first="Cédric" last="Blanpain">Cédric Blanpain</name><name sortKey="Lescroart, Fabienne" sort="Lescroart, Fabienne" uniqKey="Lescroart F" first="Fabienne" last="Lescroart">Fabienne Lescroart</name><name sortKey="Mathiah, Navrita" sort="Mathiah, Navrita" uniqKey="Mathiah N" first="Navrita" last="Mathiah">Navrita Mathiah</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rulands, Steffen" sort="Rulands, Steffen" uniqKey="Rulands S" first="Steffen" last="Rulands">Steffen Rulands</name></region><name sortKey="Rulands, Steffen" sort="Rulands, Steffen" uniqKey="Rulands S" first="Steffen" last="Rulands">Steffen Rulands</name><name sortKey="Simons, Benjamin D" sort="Simons, Benjamin D" uniqKey="Simons B" first="Benjamin D." last="Simons">Benjamin D. Simons</name><name sortKey="Simons, Benjamin D" sort="Simons, Benjamin D" uniqKey="Simons B" first="Benjamin D." last="Simons">Benjamin D. Simons</name><name sortKey="Simons, Benjamin D" sort="Simons, Benjamin D" uniqKey="Simons B" first="Benjamin D." last="Simons">Benjamin D. Simons</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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